Alta has extensive experience in the bioanalysis of pharmaceutical compounds in a variety of ocular matrices. We have developed and validated over 40 proprietary LC/MS/MS methods in a variety of ocular fluids and tissues across several species and matrices. These methods include the analysis of ocular tissue homogenates and direct measurement of intact tissues processed by high-energy sonication. Ocular matrices worked with to date include aqueous humor, vitreous humor, retina, choroid, sclera, cornea, iris, ciliary body and dose site.